|
KMID : 1134820070360030276
|
|
Journal of the Korean Society of Food Science and Nutrition
2007 Volume.36 No. 3 p.276 ~ p.283
|
|
|
Anti-atherogenic Effect of Isoflavone through Hypolipidemic, Anti-oxidative and Anti-inflammatory Actions in C57BL/6 Mice
|
|
Cho Hye-Yeon
Yang Jeong-Lye
Noh Kyung-Hee
Kim Jin-Ju
Kim Young-Hwa
Huh Kyung-Hye
Song Young-Sun
|
|
|
Abstract
|
|
|
|
This study was carried out to investigate the effect of isoflavone on the atherogenic effect in C57BL/6 mice. C57BL/6 female mice, 5 weeks of age, were fed on chow diets for 2 weeks during adjustment period. Mice weighing approximately 17.9±0.9 g were divided into 4 groups and were fed on the experimental diets containing isoflavone for 8 weeks. Experimental groups were control (atherogenic diet), IF-10 (atherogenic diet with isoflavone 10 ㎎/100 g diet), IF-40 (atherogenic diet with isoflavone 40 ㎎/100 g diet) and IF-100 (atherogenic diet with isoflavone 100 ㎎/100 g diet). Food efficiency ratio was not different among the experimental groups. Plasma triglyceride (TG) concentrations were lower after 4 weeks in isoflavone supplementation groups than in control group, whereas monocyte chemoattractant protein-1 and thiobarbituric acid reactive substances (TBARS) levels of plasma were significantly (p＜0.05) decreased in the isoflavone supplementation groups in a dose dependent manner. Both hepatic TG and cholesterol levels were significantly lowered in IF-100 than control. Hepatic glutathione concentrations were higher in the IF-100 group than in the other groups. Hepatic antioxidant enzyme activities incuding glutathione-reductase, glutathione-peroxidase, catalase, and Mn-superoxide dismutase were significantly higher in the isoflavone supplemen-tation groups in a dose dependent manner. From the above results, it is concluded that isoflavone may reduce the risk of atherosclerosis via hypolipidemic, anti-oxidative and anti-inflammatory effects.
|
|
|
KEYWORD
|
|
|
anti-oxidative and anti-inflammatory effect, antioxidant enzyme activity, atherosclerosis, isoflavone, lipid level, monocyte chemoattractant protein-1
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|